The Pharmacology of Indomethacin

@article{Lucas2016ThePO,
  title={The Pharmacology of Indomethacin},
  author={Sylvia M Lucas},
  journal={Headache: The Journal of Head and Face Pain},
  year={2016},
  volume={56}
}
  • S. Lucas
  • Published 1 February 2016
  • Medicine
  • Headache: The Journal of Head and Face Pain
Over 50 years ago, indomethacin emerged as an extremely potent non‐steroidal anti‐inflammatory drug (NSAID) during a massive effort to find effective anti‐inflammatory and analgesic medications. The 1960s saw acetic acid derivatives developed into indomethacin, diclofenac, and sulindac, and propionic derivatives into ibuprofen, naproxen, and ketoprofen. Indomethacin was likely the most potent of these compounds and one of the earliest to enter clinical trials. It is not surprising that… 
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Highly Influential Citations
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118 Citations

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Citation Type

Lipid Formulations and Bioconjugation Strategies for Indomethacin Therapeutic Advances
TLDR
This review summarizes pharmacological information about IND and analyzes its new lipid formulations and lipid bioconjugates as well as discuss their efficacy and potential application.
Review of characteristics and analytical methods for determination of indomethacin
TLDR
Indomethacin (INDO) is one of the most powerful drugs used in various clinical trials and therapies related to the mechanism of blocking prostaglandin synthesis, thus reducing and eliminating many inflammatory conditions in patients.
Limitations of drug concentrations used in cell culture studies for understanding clinical responses of NSAIDs.
In this review, the in vitro cellular effects of six nonsteroidal anti-inflammatory drugs (NSAIDs), salicylate, ibuprofen, naproxen, indomethacin, celecoxib and diclofenac, are examined. Inhibition…
Etoricoxib and celecoxib sensitive indomethacin‐responsive headache disorders
TLDR
Etoricoxib and celecoxib, selective inhibitors of cyclo‐oxygenase‐2 (COX‐2), spare gastroduodenal COX‐1 activity and are less likely to cause gastrointestinal adverse effects than indomethacin.
Using Experimental Models to Decipher the Effects of Acetaminophen and NSAIDs on Reproductive Development and Health
TLDR
The mechanisms by which NSAIDs and analgesics may impair gonadal development and maturation, puberty development, sex hormone production, maturation and function of adult organs, and ultimately fertility in the exposed animals and their offspring are discussed.
Indomethacin‐responsive headaches—A narrative review
TLDR
The so‐called indomethacin‐responsive headache disorders consist of a group of conditions with a very different presentation that have a particularly good response to indomethin, so distinct as to be used in the definition of two: hemicrania continua and paroxysmal hemic Brania.
Anti-inflammatory, Analgesic, and Cytotoxic Effects of The Phytexponent: A Polyherbal Formulation
TLDR
The Phytexponent has significant in vivo anti-inflammatory and analgesic efficacy in mice models and is not cytotoxic to Vero E6 cell line, depicting its therapeutic potential upon further empirical investigation.
Quantitative determination of new anti-inflammatory drug indomenthyl and its metabolite in rabbit plasma by HPLC-MS/MS.
TLDR
This research is aimed at developing a highly sensitive method for the quantitative determination of indomenthyl and its active metabolite indomethacin in rabbit plasma by HPLC-MS/MS.
Pyrrolidone-modified PAMAM dendrimers enhance anti-inflammatory potential of indomethacin in vitro.
Ameliorative effects of indomethacin at different concentrations on endothelial insulin resistance through two distinct pathways.
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