The Pharmacology of Indomethacin

@article{Lucas2016ThePO,
  title={The Pharmacology of Indomethacin},
  author={S. Lucas},
  journal={Headache: The Journal of Head and Face Pain},
  year={2016},
  volume={56}
}
  • S. Lucas
  • Published 2016
  • Medicine
  • Headache: The Journal of Head and Face Pain
  • Over 50 years ago, indomethacin emerged as an extremely potent non‐steroidal anti‐inflammatory drug (NSAID) during a massive effort to find effective anti‐inflammatory and analgesic medications. The 1960s saw acetic acid derivatives developed into indomethacin, diclofenac, and sulindac, and propionic derivatives into ibuprofen, naproxen, and ketoprofen. Indomethacin was likely the most potent of these compounds and one of the earliest to enter clinical trials. It is not surprising that… CONTINUE READING
    54 Citations
    Ameliorative effects of indomethacin at different concentrations on endothelial insulin resistance through two distinct pathways.
    • 1

    References

    SHOWING 1-10 OF 63 REFERENCES
    Mechanism of action of antiinflammatory drugs.
    • 344
    Clinical Pharmacokinetics of Indomethacin
    • 131
    Mechanisms of action of anti-inflammatory drugs.
    • 117
    Are altered pharmacokinetics of non-steroidal anti-inflammatory drugs (NSAIDs) a risk factor for gastrointestinal bleeding?
    • 20
    Mechanism of action of anti-inflammatory drugs.
    • 324
    Indomethacin in rheumatoid arthritis: comparison of oral and rectal dosing.
    • 19
    Pharmacokinetic overview of indomethacin and sustained-release indomethacin.
    • K. Yeh
    • Medicine
    • The American journal of medicine
    • 1985
    • 36
    Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity.
    • 18
    • PDF