The Pharmacology of Indomethacin

@article{Lucas2016ThePO,
  title={The Pharmacology of Indomethacin},
  author={Sylvia M Lucas},
  journal={Headache: The Journal of Head and Face Pain},
  year={2016},
  volume={56}
}
  • S. Lucas
  • Published 1 February 2016
  • Medicine
  • Headache: The Journal of Head and Face Pain
Over 50 years ago, indomethacin emerged as an extremely potent non‐steroidal anti‐inflammatory drug (NSAID) during a massive effort to find effective anti‐inflammatory and analgesic medications. The 1960s saw acetic acid derivatives developed into indomethacin, diclofenac, and sulindac, and propionic derivatives into ibuprofen, naproxen, and ketoprofen. Indomethacin was likely the most potent of these compounds and one of the earliest to enter clinical trials. It is not surprising that… 
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