Detection and Assay of Vitamin B6 (Pyridoxine Hydrochloride) Utilizing Isocratic High Performance Liquid Chromatography
Aims: To demonstrate an analysis for vitamin B6 from commercial aqueous nutritional drinks and solid tablets, utilizing isocratic conditions with high performance liquid chromatography (HPLC) and UV…
A Novel 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine (C21H26N2O8): Microwave-Irradiated Hantzsch Ester Synthesis, Characterization and Molecular Crystal
The novel 4-(4,5-dimethoxy-2-nitrophenyl)-2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine was synthesized through multicomponent one pot Hantzsch ester synthesis using…
A minimax approach to the single-point method of drug dosing
- PhysicsJournal of Pharmacokinetics and Biopharmaceutics
An improved method for choosing a plasma sampling time and a proportionality constant for drugs administered intravenously or to drugs whose rates of absorption from the site of administration are very rapid compared to their rates of elimination from the body is described.
A comparison of the neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in soman-poisoned rats.
- Biology, MedicineActa medica
The findings confirm that the combination of pharmacological pretreatment and antidotal treatment is able not only to protect the experimental animals from the lethal effects of soman but also to eliminate most soman-induced signs of neurotoxicity in poisoned rats.
Laparoscopy: searching for the proper insufflation gas.
- MedicineSurgical endoscopy
Clearly, CO(2) maintains its role as the primary insufflation gas in laparoscopy, but N( 2)O has a role in some cases of depressed pulmonary function or in local/regional anesthesia cases and should be used only in protocol studies.
Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins
- BiologyBritish journal of pharmacology
The aim of the present work was to use mathematical modelling to explore the potential utility of receptor binding and cellular functional assays to estimate the affinity of compounds for plasma proteins.
Finger Print of Arsenic Contaminated Water in India-A Review
The present study deals primarily with the arsenic contamination occur in ground water in all over India, its causes, effects and recommendation. Arsenic above permissible limit in ground water of…
Diuretic activity of squamate mistletoe, Viscum angulatum
- BiologyPharmaceutical biology
HPLC and quantitative analysis of the methanol extract revealed that polyphenolic compounds and the triterpenoid, oleanolic acid, are the major phytochemicals, and are proposed to be responsible for the observed diuretic effect.
Involvement of Human Multidrug and Toxin Extrusion 1 in the Drug Interaction between Cimetidine and Metformin in Renal Epithelial Cells
- Biology, MedicineJournal of Pharmacology and Experimental Therapeutics
Results suggest that apical hMATE1 is involved in drug interactions between cimetidine and cationic compounds in the proximal tubular epithelial cells.
7-12 Hz high-voltage rhythmic spike discharges in rats evaluated by antiepileptic drugs and flicker stimulation.
- Biology, PsychologyJournal of neurophysiology
The hypothesis that HVRS activity in Long-Evans rats may be an absence-like seizure activity rather than the mu rhythm is supported.