The Pharmacologic and Clinical Effects of Medical Cannabis

@article{Borgelt2013ThePA,
  title={The Pharmacologic and Clinical Effects of Medical Cannabis},
  author={Laura M Borgelt and Kari L. Franson and Abraham M. Nussbaum and George Sam Wang},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2013},
  volume={33}
}
Cannabis, or marijuana, has been used for medicinal purposes for many years. Several types of cannabinoid medicines are available in the United States and Canada. Dronabinol (schedule III), nabilone (schedule II), and nabiximols (not U.S. Food and Drug Administration approved) are cannabis‐derived pharmaceuticals. Medical cannabis or medical marijuana, a leafy plant cultivated for the production of its leaves and flowering tops, is a schedule I drug, but patients obtain it through cannabis… 
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References

SHOWING 1-10 OF 105 REFERENCES
Cannabis and Its Derivatives: Review of Medical Use
  • L. Leung
  • Medicine
    The Journal of the American Board of Family Medicine
  • 2011
TLDR
Family physicians need to be cognizant of such changing landscapes with a practical knowledge on the pros and cons of medical marijuana, the legal implications of its use, and possible developments in the future.
Medical marijuana and the developing role of the pharmacist.
PURPOSE The pharmacology, therapeutic uses, safety, drug-drug interactions, and drug-disease interactions of medical marijuana are reviewed, and the legal issues related to its use and the
Medicinal use of cannabis in the United States: historical perspectives, current trends, and future directions.
TLDR
The current and emerging research on the physiological mechanisms of cannabinoids and their applications in managing chronic pain, muscle spasticity, cachexia, and other debilitating problems are reviewed.
Examining the roles of cannabinoids in pain and other therapeutic indications: a review
TLDR
It is important that cannabinoids not be considered ‘first-line’ therapies for conditions for which there are more supported and better-tolerated agents and instead these agents could be considered in a situation of treatment failure with standard therapies or as adjunctive agents where appropriate.
Biomarkers for the effects of cannabis and THC in healthy volunteers.
An increasing number of novel therapeutic agents are targeted at cannabinoid receptors. Drug development programmes of new cannabinoid drugs may be facilitated by the identification of useful
Pain relief with oral cannabinoids in familial Mediterranean fever
TLDR
This is the first United Kingdom report of the controlled use of a standardised pharmaceutical preparation of cannabinoids in capsular form and a highly significant reduction in additional analgesic requirements was achieved.
Adverse effects of medical cannabinoids: a systematic review
TLDR
Short-term use of existing medical cannabinoids appeared to increase the risk of nonserious adverse events, and high-quality trials of long-term exposure are required to further characterize safety issues related to the use of medical cannabinoids.
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