The Pharmacokinetics of Taurolidine Metabolites in Healthy Volunteers

@article{Gong2007ThePO,
  title={The Pharmacokinetics of Taurolidine Metabolites in Healthy Volunteers},
  author={Li Gong and Howard E. Greenberg and James L. Perhach and Scott A. Waldman and Walter K. Kraft},
  journal={The Journal of Clinical Pharmacology},
  year={2007},
  volume={47}
}
Taurolidine is an experimental antibacterial and antiendotoxic compound whose clinical utility as an antitumor agent is being investigated in human clinical trials. Taurolidine in aqueous solution exists in equilibrium with taurultam. Taurultam is subsequently transformed to taurinamide. The pharmacokinetic profiles of these metabolites are not well established. In this study, 18 healthy volunteers were administered 5.0 g of taurolidine in 250 mL of 5% polyvinylpyrrolidone in water over 2, 1… 
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Results indicated that TRD may contribute to cell apoptosis by inducing GRIM‑19 expression and deactivating the STAT3 signaling pathway in liver cancer cells.
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References

SHOWING 1-10 OF 31 REFERENCES
Effect of the antiendotoxic agent, taurolidine, in the treatment of sepsis syndrome: a placebo-controlled, double-blind trial.
TLDR
Taurolidine had no beneficial therapeutic effect on the outcome of patients admitted to the intensive therapy unit with sepsis syndrome, using clinical, bacteriologic outcomes, progression of endotoxemia, resolution of organ failure, and 28-day mortality rate as end points.
Taurolidine, an antilipopolysaccharide agent, has immunoregulatory properties that are mediated by the amino acid taurine
TLDR
In addition to its bactericidal and antilipopolysaccharide activity, taurolidine primes PMØs for enhanced antimicrobial activity and these effects appear mediated by the amino acid taurine.
Taurolidine: cytotoxic and mechanistic evaluation of a novel antineoplastic agent.
TLDR
Assessment of the antiproliferative activity of this agent in selected human and murine tumor cell lines found it inhibited both tumor formation and growth and increased the appearance of DNA debris in the sub-G(0)/G(1) region, an effect consistent with an induction of apoptosis.
The in vitro and in vivo activity of taurolin against anaerobic pathogenic organisms.
TLDR
Intravenously administered taurolin protects rabbits from the effects of Bacteroides fragilis infection whether the organisms are given intravenously or intraperitoneally.
Taurolidine–a new drug with anti-tumor and anti-angiogenic effects
TLDR
Taurolidine significantly reduces the pathogenicity of prokaryotes, leading to a degeneration of the bacterial wall, and binds free lipoplysaccharides (LPSs) and exotoxins, and inhibits protein synthesis at an early phase of translation, which might explain its various apoptotic effects.
Taurolidine Inhibits Tumor Cell Growth In Vitro and In Vivo
TLDR
Taurolidine inhibits the growth of a rat metastatic colorectal tumor cell line in vitro and in vivo and thus may have potential in the prevention of peritoneal metastases.
The Effects of Taurolidine, a Novel Antineoplastic Agent, on Human Malignant Mesothelioma
TLDR
Taurolidine has significant antineoplastic activity against MM in vitro and in vivo, in part, due to tumor cell apoptosis, and warrant further study for potential clinical usefulness.
Taurolidine inhibits tumour necrosis factor (TNF) toxicity--new evidence of TNF and endotoxin synergy.
  • J. Monson, P. Ramsey, J. Donohue
  • Medicine, Biology
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • 1993
TLDR
It was demonstrated in cotherapy studies in a murine model that taurolidine did not reduce the anti-tumour efficacy of TNF against the TNF sensitive mouse fibrosarcoma cell line Meth-A sarcoma and this was likely to be due to interference with the synergistic effects of endotoxin and TNF.
Local and systemic chemotherapy with taurolidine and taurolidine/heparin in colon cancer-bearing rats undergoing laparotomy
TLDR
Intraperitoneal therapy of either taurolidine or in combination with heparin inhibits local tumor growth and abdominal wound recurrences in rats undergoing midline laparotomy.
NMR studies and GC analysis of the antibacterial agent taurolidine.
TLDR
The NMR spectrum of taurolidine in deuterium oxide was compared with spectra obtained from model experiments with amines and formaldehyde and showed that there was less than 0.004% free formaldehyde present in 2% solutions of t Taurolidine.
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