The Pharmacokinetics and Pharmacodynamics of Atracurium in Patients with and without Renal Failure

@article{Fahey1984ThePA,
  title={The Pharmacokinetics and Pharmacodynamics of Atracurium in Patients with and without Renal Failure},
  author={M. Fahey and S. Rupp and D. Fisher and R. Miller and M. Sharma and C. Canfell and K. Castagnoli and P. Hennis},
  journal={Anesthesiology},
  year={1984},
  volume={61},
  pages={699–702}
}
  • M. Fahey, S. Rupp, +5 authors P. Hennis
  • Published 1984
  • Medicine
  • Anesthesiology
  • To determine the influence of renal function on the pharmacology of atracurium, 10 patients with normal renal function and 10 with renal failure (scheduled for cadaver kidney transplant) were anesthetized with nitrous oxide and halothane. Atracurium besylate, 0.5 mg·kg−1, was given as an iv bolus and plasma samples were collected over a 4-h period. These samples were assayed for atracurium (all patients) and laudanosine, one of the principal metabolites (eight of the normal group), using an ion… CONTINUE READING
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