The Pharmacokinetic and Safety Profiles of Blonanserin in Healthy Chinese Volunteers After Single Fasting Doses and Single and Multiple Postprandial Doses

@article{Chen2014ThePA,
  title={The Pharmacokinetic and Safety Profiles of Blonanserin in Healthy Chinese Volunteers After Single Fasting Doses and Single and Multiple Postprandial Doses},
  author={Xia Chen and Hongyun Wang and Ji Jiang and Rui Chen and Ying Zhou and Wen Zhong and Hongzhong Liu and Pei Hu},
  journal={Clinical Drug Investigation},
  year={2014},
  volume={34},
  pages={213-222}
}
Background and ObjectivesBlonanserin is a novel atypical antipsychotic drug acting as a mixed serotonin 5-HT2A and dopamine D2 receptor antagonist. This study investigated the pharmacokinetics and safety of blonanserin in healthy Chinese males.MethodsThis was an open-label trial with two parts. Twenty-four subjects were enrolled in part A to receive a single fasting dose of 4 or 8 mg blonanserin (each n = 12); part B recruited 12 subjects and administered single and sequentially twice-daily… 

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