Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB.
- BiologyThe international journal of neuropsychopharmacology
Genetic variation in HTR2A that was previously associated with citalopram treatment outcome was also associated with thalamic 5-HTT binding, suggesting that a relationship exists between genetic variations in H TR2A and either 5-htT expression or central serotonergic transmission that influences the therapeutic response to 5- HTT inhibition in major depression.
The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case–control association study
- BiologyInternational clinical psychopharmacology
It is shown that none of the seven COMT SNPs, including the rs4680, was significantly associated with MDD after permutation correction in single SNP analyses, which suggests that the polymorphic COMT gene that influences catecholaminergic neurotransmission may play a role in the individual response to antidepressants.
Genetic variables of the glutamatergic system associated with treatment-resistant depression: A review of the literature
- BiologyWorld journal of psychiatry
A literature search was performed to identify studies on the genetics of the glutamatergic system in depression, focused on variables related to NMDARs and AMPARs, and highlights GRIN2B, which encodes the NR2B subunit of N MDAR, as a candidate gene in the pathogenesis of TRD.
P.505 The potential role of BDNF and prolactin genotypes on antidepressant response in depressive patients
- PsychologyEuropean Neuropsychopharmacology
Investigating the potential role of BDNF and PRL genotypes on antidepressant response in depression patients: A prospective inception cohort study in treatment-free patients.
- Psychology, MedicineJournal of affective disorders
Genetic variation in HTR 2 A influences serotonin transporter binding potential as measured using PET and [ 11 C ] DASB
While further work is needed to identify the actual functional genetic variants involved, these results suggest that a relationship exists between genetic variation in HTR2A and either 5- HTT expression or central serotonergic transmission that influences the therapeutic response to 5-HTT inhibition in major depression.
Pharmacogenetics of Antidepressant Drugs: An Update
- Biology, Psychology
The major findings related to the pharmacogenetics of genes involved in the pharmacokinetics and pharmacodynamics of antidepressant drugs are critically reviewed.
Pharmacogenetic Randomized Trial for Cocaine Abuse: Disulfiram and Dopamine β-Hydroxylase
- Medicine, PsychologyBiological Psychiatry
DBH gene as predictor of response in a cocaine vaccine clinical trial
- Biology, PsychologyNeuroscience Letters
SHOWING 1-10 OF 22 REFERENCES
Genetic associations in large versus small studies: an empirical assessment
- Psychology, BiologyThe Lancet
Predictors of response to antidepressants general principles and clinical implications.
- Psychology, MedicineThe Psychiatric clinics of North America
Pharmacogenetic studies of antidepressant response: how far from the clinic?
- Medicine, PsychologyThe Psychiatric clinics of North America
Translating Pharmacogenomics: Challenges on the Road to the Clinic
- Medicine, BiologyPLoS medicine
This article presents specific clinical examples of such challenges and discusses how obstacles to implementation of pharmacogenomic testing can be addressed and how the application in patient care remains very limited.
Evidence-Based Health Policy--Lessons from the Global Burden of Disease Study
- Medicine, Political ScienceScience
The study, which includes projections of the burden through the year 2020, uses the disability-adjusted life year as a composite measure of years of life lost due to premature mortality and years lived with disability.
Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment.
- PsychologyAmerican journal of human genetics
There is a compelling case for a key role of HTR2A in the mechanism of antidepressant action, as detected in patients treated with the antidepressant citalopram.
Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region
Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting…
Pharmacogenomics and antidepressant drugs
- BiologyAnnals of medicine
These studies mark the beginning of an emerging standard SNP profiling system that ultimately allows identifying the right drug for the right patient at the right time.
Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design.
- PsychologyControlled clinical trials