The Pfam protein families database: towards a more sustainable future

@article{Finn2016ThePP,
  title={The Pfam protein families database: towards a more sustainable future},
  author={Robert D. Finn and Penny C. Coggill and Ruth Y. Eberhardt and Sean R. Eddy and Jaina Mistry and Alex L. Mitchell and Simon C. Potter and Marco Punta and Matloob Qureshi and Amaia Sangrador-Vegas and Gustavo A. Salazar and John G. Tate and Alex Bateman},
  journal={Nucleic Acids Research},
  year={2016},
  volume={44},
  pages={D279 - D285}
}
In the last two years the Pfam database (http://pfam.xfam.org) has undergone a substantial reorganisation to reduce the effort involved in making a release, thereby permitting more frequent releases. Arguably the most significant of these changes is that Pfam is now primarily based on the UniProtKB reference proteomes, with the counts of matched sequences and species reported on the website restricted to this smaller set. Building families on reference proteomes sequences brings greater… 
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References

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