The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.

@article{Karuman2001ThePG,
  title={The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.},
  author={Philip Karuman and Or P Gozani and Robert D Odze and Xun Clare Zhou and Hong Fei Zhu and Reuben Shaw and Thomas P Brien and C D Bozzuto and Daylily S Ooi and Lewis C. Cantley and Junying Yuan},
  journal={Molecular cell},
  year={2001},
  volume={7 6},
  pages={1307-19}
}
Here, we investigate the mechanism and function of LKB1, a Ser/Thr kinase mutated in Peutz-Jegher syndrome (PJS). We demonstrate that LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways. LKB1 protein is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. In vivo, LKB1 is highly upregulated in pyknotic intestinal epithelial cells. In contrast, polyps arising in Peutz-Jegher patients are devoid of… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
Blog posts, news articles and tweet counts and IDs sourced by
Altmetric.com