The Peroxisome Proliferator-Activated Receptor-γ Agonist Rosiglitazone Increases Bone Resorption in Women with Type 2 Diabetes: A Randomized, Controlled Trial

@article{Gruntmanis2010ThePP,
  title={The Peroxisome Proliferator-Activated Receptor-γ Agonist Rosiglitazone Increases Bone Resorption in Women with Type 2 Diabetes: A Randomized, Controlled Trial},
  author={Ugis Gruntmanis and Steve V E Fordan and Hans K. Ghayee and S. M. Rubaiot Abdullah and Raphael See and Colby R. Ayers and Darren K McGuire},
  journal={Calcified Tissue International},
  year={2010},
  volume={86},
  pages={343-349}
}
In previous studies, with up to 16 weeks of exposure to rosiglitazone or pioglitazone, circulating markers of bone formation [procollagen I N-terminal propeptide (P1NP), osteocalcin, and bone-specific alkaline phosphatase] decreased but no change in bone resorption markers was found. We examined the effect of rosiglitazone on bone resorption and formation markers when used for 24 weeks. This post-hoc analysis of a double-blind, placebo-controlled, randomized trial evaluated the effects of 6… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 34 references

PPAR-gamma regulates osteoclastogenesis in mice.

Nature medicine • 2007
View 4 Excerpts
Highly Influenced

Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne • 2009
View 1 Excerpt

Use of thiazolidinediones and fracture risk.

Archives of internal medicine • 2008
View 2 Excerpts

Diabetes drug pioglitazone (Actos): risk of fracture.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne • 2007
View 1 Excerpt

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