The Pep4p vacuolar proteinase contributes to the turnover of oxidized proteins but PEP4 overexpression is not sufficient to increase chronological lifespan in Saccharomyces cerevisiae.

@article{Marques2006ThePV,
  title={The Pep4p vacuolar proteinase contributes to the turnover of oxidized proteins but PEP4 overexpression is not sufficient to increase chronological lifespan in Saccharomyces cerevisiae.},
  author={Marta Marques and Dominik Mojzita and Maria Am{\'e}lia Amorim and Lara Ribeiro de Almeida and Stefan Hohmann and Pedro Moradas-Ferreira and V{\'i}tor Costa},
  journal={Microbiology},
  year={2006},
  volume={152 Pt 12},
  pages={
          3595-605
        }
}
Turnover of damaged molecules is considered to play a key role in housekeeping of cells exposed to oxidative stress, and during the progress of ageing. In this work, global changes in the transcriptome were analysed during recovery of yeast cells after H(2)O(2) stress. Regarding induced genes, those associated with protein fate were the most significantly over-represented. In addition to genes encoding subunits of the 20S proteasome, genes related to vacuolar proteolysis (PEP4 and LAP4… CONTINUE READING

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