The Pco proteins are involved in periplasmic copper handling in Escherichia coli.

  title={The Pco proteins are involved in periplasmic copper handling in Escherichia coli.},
  author={Sun Mi Lee and Gregor Grass and Christopher Rensing and Siobh{\'a}n R Barrett and Christopher J D Yates and Jivko V. Stoyanov and Nigel L. Brown},
  journal={Biochemical and biophysical research communications},
  volume={295 3},
The interactions between the plasmid-borne copper resistance determinant, pco, and the main copper export system in Escherichia coli have been investigated and no direct interaction has been found. The PcoE and PcoC proteins are periplasmic and PcoC binds one Cu ion per protein molecule. PcoA is also periplasmic and can substitute for the chromosomally encoded CueO protein. The pco determinant is proposed to exert its effect through periplasmic handling of excess copper ions and to increase the… CONTINUE READING

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