The Pbx Interaction Motif of Hoxa1 Is Essential for Its Oncogenic Activity

Abstract

Hoxa1 belongs to the Hox family of homeodomain transcription factors involved in patterning embryonic territories and governing organogenetic processes. In addition to its developmental functions, Hoxa1 has been shown to be an oncogene and to be overexpressed in the mammary gland in response to a deregulation of the autocrine growth hormone. It has… (More)
DOI: 10.1371/journal.pone.0025247

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