The PavA-like fibronectin-binding protein of Enterococcus faecalis, EfbA, is important for virulence in a mouse model of ascending urinary tract infection.

@article{Torelli2012ThePF,
  title={The PavA-like fibronectin-binding protein of Enterococcus faecalis, EfbA, is important for virulence in a mouse model of ascending urinary tract infection.},
  author={R. Torelli and Pascale Serror and Francesca Bugli and Francesco Paroni Sterbini and Ada Rita Florio and Annarita Stringaro and Marisa Colone and Elena De Carolis and C{\'e}cilia Martini and J. C. Giard and Maurizio Sanguinetti and Brunella Posteraro},
  journal={The Journal of infectious diseases},
  year={2012},
  volume={206 6},
  pages={952-60}
}
Enterococcus faecalis is an established nosocomial pathogen, yet the pathogenesis of enterococcal infections, particularly of urinary tract infections (UTIs), remains to be fully elucidated. Fibronectin-binding proteins have been identified as potent adhesins in pathogenic Gram-positive cocci. Here, we characterized EfbA, which is encoded by the enterococcal orthologue of Streptococcus pneumoniae pavA. Similar to PavA, the anchorless EfbA protein was localized to the enterococcal cell outer… CONTINUE READING

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