The Pattern of Gene Amplification Is Determined by the Chromosomal Location of Hairpin-Capped Breaks

@article{Narayanan2006ThePO,
  title={The Pattern of Gene Amplification Is Determined by the Chromosomal Location of Hairpin-Capped Breaks},
  author={Vidhya Narayanan and Piotr A. Mieczkowski and Hyun-Min Kim and Thomas D Petes and Kirill S Lobachev},
  journal={Cell},
  year={2006},
  volume={125},
  pages={1283-1296}
}
DNA palindromes often colocalize in cancer cells with chromosomal regions that are predisposed to gene amplification. The molecular mechanisms by which palindromes can cause gene amplification are largely unknown. Using yeast as a model system, we found that hairpin-capped double-strand breaks (DSBs) occurring at the location of human Alu-quasipalindromes lead to the formation of intrachromosomal amplicons with large inverted repeats (equivalent to homogeneously staining regions in mammalian… CONTINUE READING
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