The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins

  title={The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins},
  author={Triantafyllos Chavakis and Angelika Bierhaus and Nadia Al-Fakhri and Darius Schneider and Steffen Witte and Thomas Linn and Mariko Nagashima and John Morser and Bernd Arnold and Klaus Theo Preissner and Peter P Nawroth},
  journal={The Journal of Experimental Medicine},
  pages={1507 - 1515}
The pattern recognition receptor, RAGE (receptor for advanced glycation endproducts), propagates cellular dysfunction in several inflammatory disorders and diabetes. Here we show that RAGE functions as an endothelial adhesion receptor promoting leukocyte recruitment. In an animal model of thioglycollate-induced acute peritonitis, leukocyte recruitment was significantly impaired in RAGE-deficient mice as opposed to wild-type mice. In diabetic wild-type mice we observed enhanced leukocyte… CONTINUE READING
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