The Pathophysiology of LETM1

  title={The Pathophysiology of LETM1},
  author={Karin Nowikovsky and Tullio Pozzan and Rosario Rizzuto and Luca Scorrano and Paolo Bernardi},
  booktitle={The Journal of general physiology},
Originally identified as a key element of mitochondrial volume homeostasis through regulation of K + –H + exchange (KHE), the LETM1 protein family is also involved in respiratory chain biogenesis and in the pathogenesis of seizures in the Wolf–Hirschhorn syndrome (WHS). To add further complexity, LETM1 has been recently proposed to catalyze mitochondrial H + –Ca 2+ exchange, which would imply a role in mitochondrial Ca 2+ homeo-stasis as well. In the following paragraphs, we summarize the… CONTINUE READING
19 Extracted Citations
60 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 19 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 60 references

Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae

  • K. S. Dimmer, F. Navoni, +5 authors L. Scorrano
  • Mol . Biol . Cell .
  • 2008
Highly Influential
8 Excerpts

A genome - wide transgenic RNAi library for conditional gene inactivation in Drosophila

  • S. DiMauro, C. Garone
  • Nature .
  • 2011
1 Excerpt

Similar Papers

Loading similar papers…