The Pathology of MS: New Insights and Potential Clinical Applications

@article{Pittock2007ThePO,
  title={The Pathology of MS: New Insights and Potential Clinical Applications},
  author={S. Pittock and C. Lucchinetti},
  journal={The Neurologist},
  year={2007},
  volume={13},
  pages={45-56}
}
  • S. Pittock, C. Lucchinetti
  • Published 2007
  • Medicine
  • The Neurologist
  • Background:The pathological hallmarks of the multiple sclerosis (MS) lesion consist of focal demyelination, inflammation, scar formation, and variable axonal destruction. Despite years of classical histopathological study and more recent intensive use of magnetic resonance technology, the MS lesion is incompletely understood. How it is initiated, how it changes over time, how it correlates with clinical symptoms and other markers of disease activity, and how it is impacted by therapeutic… CONTINUE READING
    114 Citations

    Topics from this paper

    Perfusion and Diffusion Abnormalities of Multiple Sclerosis Lesions and Relevance of Classified Lesions to Disease Status
    • 6
    • PDF
    An Animal Model of Cortical and Callosal Pathology in Multiple Sclerosis
    • 69
    MS: Pathology and Immunology
    • 2

    References

    SHOWING 1-10 OF 127 REFERENCES
    Axonal injury in multiple sclerosis
    • K. Rammohan
    • Medicine
    • Current neurology and neuroscience reports
    • 2003
    • 56
    Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • 2,887
    • PDF
    Clinical course, pathological correlations, and outcome of biopsy proved inflammatory demyelinating disease
    • 51
    • PDF
    Multiple sclerosis: lessons from neuropathology.
    • 110
    Axonal damage in acute multiple sclerosis lesions.
    • 1,474
    • PDF
    Axonal injury in multiple sclerosis
    • H. Lassmann
    • Medicine
    • Journal of neurology, neurosurgery, and psychiatry
    • 2003
    • 64
    • PDF
    Axonal transection in the lesions of multiple sclerosis.
    • 3,733
    Axonal Pathology in Multiple Sclerosis. A Historical Note
    • 196
    Cortical demyelination and diffuse white matter injury in multiple sclerosis.
    • 1,437
    • PDF
    The pathology of multiple sclerosis and its evolution.
    • H. Lassmann
    • Medicine
    • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
    • 1999
    • 89