The Pathology of MS: New Insights and Potential Clinical Applications

  title={The Pathology of MS: New Insights and Potential Clinical Applications},
  author={S. Pittock and C. Lucchinetti},
  journal={The Neurologist},
  • S. Pittock, C. Lucchinetti
  • Published 2007
  • Medicine
  • The Neurologist
  • Background:The pathological hallmarks of the multiple sclerosis (MS) lesion consist of focal demyelination, inflammation, scar formation, and variable axonal destruction. Despite years of classical histopathological study and more recent intensive use of magnetic resonance technology, the MS lesion is incompletely understood. How it is initiated, how it changes over time, how it correlates with clinical symptoms and other markers of disease activity, and how it is impacted by therapeutic… CONTINUE READING
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