The Pathology of Acute Yellow Atrophy and Delayed Chloroform Poisoning

@article{Sheehan1940ThePO,
  title={The Pathology of Acute Yellow Atrophy and Delayed Chloroform Poisoning},
  author={Heather L Sheehan},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
  year={1940},
  volume={47}
}
  • H. Sheehan
  • Published 1 February 1940
  • Medicine
  • BJOG: An International Journal of Obstetrics & Gynaecology
THE literature contains a number of cases reported under the title of acute yellow atrophy of the liver in pregnancy. Many of these may be discarded from the present consideration, since the diagnosis was based only on, clinical grounds or on post-mortem examination without any histology. An analysis of the cases in which investigation was adequate reveals a variety of different conditions which may be discussed in three main categories: true acute yellow atrophy, obstetric acute yellow atrophy… 

A CASE OF OBSTETRICAL ACUTE YELLOW ATROPHY OF THE LIVER

  • A. G. Edwards
  • Medicine
    The Journal of obstetrics and gynaecology of the British Empire
  • 1960
The lesion within the liver is that of a massive fatty infiltration, particularly marked in the central area of the lobule, which is unfortunate that liver biopsy was omitted, but the patient’s condition made this investigation undesirable.

Infectious hepatitis in pregnancy.

  • A. Mickal
  • Medicine
    American journal of obstetrics and gynecology
  • 1951

Obstetric Acute Yellow Atrophy

It was, however, Sheehan in 1940 who first recognized “obstetric acute yellow atrophy” as a distinct clinical entity and since then just over 40 cases have been reported.

A CASE OF ACUTE FATTY LIVER OF PREGNANCY

A case of acute fatty liver of pregnancy, with an enlarged liver weighing 3,850 gm, is reported, with the onset is sudden, the course very acute with profound jaundice, bile in the urine, delirium, coma and death.

ACUTE FATTY LIVER OF PREGNANCY. REPORT OF TWO CASES.

To date at least 39 patients with this syndrome have been described and the cases presented by Barry and O'Dwyer, 18 Dill (case VI), 19 and Cullinan (case A) 11 also may be described.

TETRACYCLINE TOXICITY IN PREGNANCY. LIVER AND PANCREATIC DYSFUNCTION.

Patients treated for pyelonephritis closely resemble those in reported cases of obstetrical acute yellow atrophy, a disorder of unknown etiology and it is suggested that this latter clinical syndrome may result from various etiological factors, including drugs, one of which is tetracycline.

ACUTE LIVER FAILURE IN PREGNANCY

The characteristic feature distinguishing the disease from viral hepatitis has been the histology of the liver, which always showed gross fatty change with a fine foam-like appearance of the cells without necrosis, which has led to the adoption of the term “acute fatty metamorphosis of the Liver”, and it is retained in this report of a case in which both mother and child survived.

Acute fatty liver of pregnancy. A reassessment based on observations in nine patients

The concurrence of this disorder with toxemia of pregnancy suggests that these entities may be pathophysiologically related, and the diagnosis was initially misinterpreted as hepatitis.
...

References

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The Pathology of Hyperemesis and Vomiting of Late Pregnancy

A study was made of cases which had come to post-mortem in this hospital within the last 10 years, and in which adequate histological material had been preserved, and found that they are free from interfering factors, and are sufficiently numerous to form a basis for conclusions.

CHLOROFORM NECROSIS OF THE LIVER.

A study of both the pathologic anatomy and the chemistry of a typical case, which I had the opportunity of examining at autopsy, and to consider certain features illustrated by this case and those so far recorded in the literature.

Acute Yellow Atrophy

It will be noted that in the cases qlinically "doubtful," but ultimately established as poliomyelitis, the cerebrospinal fluids showed either pleocytosis or significant changes in chemical composition, sometimes both, while on the other hand complete normality of the fluid in all respects enabled policyelitis to be excluded in the great majority of cases.

Note on the Ketone Content of the Blood in Labour and Pre‐eclamptic Toxaemia

With a view to arriving at a more accurate estimate oi the degree of ketosis, the blood of patients in labour was examined with regard to its acetone and diacetic acid content, and a similar analysis was carried out in a few cases of preeclamptic toxaemia.

THE INFLUENCE OF FASTING AND VARIOUS DIETS ON THE LIVER INJURY EFFECTED BY CHLOROFORM ANESTHESIA: PAPER I

The evidence shows that a unit injury due to a unit chloroform anesthesia under fasting conditions will be repeated accurately again and again, provided the dog is given sufficient time to repair each injury to normal.

THE INFLUENCE OF DIET UPON NECROSIS CAUSED BY HEPATIC AND RENAL POISONS

Diet exerts a profound influence upon the toxicity (tested in the omnivorous white rat) of certain substances, namely, chloroform, phosphorus, potassium chromate, and uranium nitrate, which cause