The Pathogenicity of Cytomegalovirus in Inflammatory Bowel Disease: A Systematic Review and Evidence-based Recommendations for Future Research

@article{Hommes2004ThePO,
  title={The Pathogenicity of Cytomegalovirus in Inflammatory Bowel Disease: A Systematic Review and Evidence-based Recommendations for Future Research},
  author={Daniel W. Hommes and Gerben J. Sterringa and Sander J. H. van Deventer and Guido N. J. Tytgat and Jan F. L. Weel},
  journal={Inflammatory Bowel Diseases},
  year={2004},
  volume={10},
  pages={245-250}
}
During recent years, a clear association between complicated courses of ulcerative colitis and the presence of cytomegalovirus (CMV) has been established. The exact pathogenic role of CMV in these patients remains unclear despite a great number of published reports. Therefore, we undertook a systematic review to appraise critically all available evidence ìn the literature on the role of CMV during inflammatory bowel disease. We identified and analyzed more than 30 case reports and 9 case series… Expand
Review article: cytomegalovirus and inflammatory bowel disease
TLDR
The outcome for patients with CMV reactivation appears worse than that for patients without reactivation, but it is not entirely clear whether CMV is a contributor or a bystander and if treatment with anti‐virals alters the course of inflammatory bowel disease (IBD). Expand
Prevalence of cytomegalovirus infection in steroid-refractory Crohn's disease.
TLDR
The prevalence of CMV infection in patients with steroid-refractory CD when compared to that reported in UC patients was assessed in 60 consecutive adult patients exhibiting moderate to severe acute flare of IBD. Expand
Cytomegalovirus colitis in children with inflammatory bowel disease
TLDR
The cases of six children followed for IBD who presented with relapse of their disease, a concomitant CMV colitis, were reported, five were steroid resistant and one infliximab resistant. Expand
Cytomegalovirus complicating inflammatory bowel disease: a 10-year experience in a community-based, university-affiliated hospital.
TLDR
Although CMV disease is relatively uncommon in IBD patients, its presence may designate an increased risk for colectomy for reasons that are not yet clear, and systematic prospective studies could help determine the true effects of CMV on IBD Patients. Expand
Low frequency of cytomegalovirus infection during exacerbations of inflammatory bowel diseases
TLDR
Results showed infrequent CMV detection in colonic biopsies of IBD patients during exacerbation leaving open the question of the relationship between CMV reactivation and the onset or the severity of I BD exacerbation. Expand
Cytomegalovirus infection and steroid-refractory inflammatory bowel disease: possible relationship from an updated meta-analysis
TLDR
This meta-analysis disclosed 2.34 fold increased risk of progressing into steroid-refractory IBD in CMV (+) group compared with the CMV (−) group, indicating that CMV infection might be a plausible cause of steroid- Refractor IBD. Expand
Cytomegalovirus in inflammatory bowel disease: Pathogen or innocent bystander?
TLDR
The immunobiology of CMV disease, the evidence for CMV's role in disease severity, and the outcomes with antiviral therapy are reviewed, and some patients with severe colitis to avoid colectomy despite poor response to conventional IBD therapies are discussed. Expand
Relationship Between Cytomegalovirus Infection and Steroid Resistance in Inflammatory Bowel Disease: A Meta-Analysis
TLDR
It is suggested thatCMV-positive IBD patients have a nearly double risk of steroid resistance compared with CMV-negative IBD Patients, indicating that CMV infection is a probable cause of steroid-resistant IBD. Expand
Acute Cytomegalovirus Infection Is a Risk Factor in Refractory and Complicated Inflammatory Bowel Disease
TLDR
CMV IHC is significantly more sensitive than routine H & E stain and should be considered as part of the routine evaluation of IBD patients with severe exacerbation or steroid-refractory disease before proceeding with other medical or surgical therapy that may not be necessary once the CMV is treated. Expand
Toward an Algorithm for the Diagnosis and Management of CMV in Patients with Colitis
TLDR
Diagnostic-based patient selection and treatment is integral to optimal outcomes in CMV, and therefore an algorithm based on these concepts that now requires prospective evaluation is proposed. Expand
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