The Pathogenic Transforming Growth Factor-β Overdrive Hypothesis in Aortic Aneurysms and Dissections: A Mirage?

Abstract

Syndromic thoracic aortic aneurysms and dissections (TAADs) develop in patients with connective tissue disorders because of genetic mutations that affect structural components of the extracellular matrix and the cell contractile machinery. Early pathogenic hypotheses attributed the aortopathy to structural failure of the aortic tissue. Over 14 years ago… (More)
DOI: 10.1161/CIRCRESAHA.116.310371

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Cite this paper

@article{Mallat2017ThePT, title={The Pathogenic Transforming Growth Factor-β Overdrive Hypothesis in Aortic Aneurysms and Dissections: A Mirage?}, author={Ziad Mallat and Hafid Ait-Oufella and Alain Tedgui}, journal={Circulation research}, year={2017}, volume={120 11}, pages={1718-1720} }