The Past, Present, and Future of Immune Repertoire Biology – The Rise of Next-Generation Repertoire Analysis

@inproceedings{Six2013ThePP,
  title={The Past, Present, and Future of Immune Repertoire Biology – The Rise of Next-Generation Repertoire Analysis},
  author={Adrien Six and Maria Encarnita Mariotti-Ferrandiz and Wahiba Chaara and Susana Magadan and Hang Phuong Pham and Marie-Paule Lefranc and Thierry Mora and Veronique Thomas-Vaslin and Aleksandra M. Walczak and Pierre Boudinot},
  booktitle={Front. Immunol.},
  year={2013}
}
T and B cell repertoires are collections of lymphocytes, each characterized by its antigen-specific receptor. We review here classical technologies and analysis strategies developed to assess immunoglobulin (IG) and T cell receptor (TR) repertoire diversity, and describe recent advances in the field. First, we describe the broad range of available methodological tools developed in the past decades, each of which answering different questions and showing complementarity for progressive… CONTINUE READING