The Part Played by Recurrent Mutation in Evolution

  title={The Part Played by Recurrent Mutation in Evolution},
  author={John Burdon Sanderson Haldane},
  journal={The American Naturalist},
  pages={5 - 19}
  • J. Haldane
  • Published 1 January 1933
  • Biology
  • The American Naturalist
Recurrent mutations not only provide the material for selection to act upon. They may give rise to primary and secondary effects, the former due to the accumulation of mutant genes, the latter to the selective value of conditions which protect the organism against lethal genes. Among the phenomena which can be accounted for by these phenomena are the disappearance of useless organs, recapitulation and the fact that the heterogametic sex is usually male. 
Population-Genetic Models of the Fates of Duplicate Genes
The ultimate fate of a duplicated gene is that it either silenced through inactivating mutations or both copies are maintained by selection, and these three different fates involve often very subtle iterations between of population size, mutation rate, and selection. Expand
A common framework for understanding the origin of genetic dominance and evolutionary fates of gene duplications.
Haplo(in)sufficiency of a gene and its propensity for duplication might have a common evolutionary basis, supporting the idea that gene dosage could be important for the initial fixation of duplications. Expand
Ploidy and the causes of genomic evolution.
Experimental evolution studies, primarily using the yeast Saccharomyces cerevisiae, provide insights into the immediate fitness effects of ploidy mutations, the ability of organisms of different ploidY levels to mask deleterious mutations, and the impact of ploids on rates of adaptation. Expand
Population genetic models of duplicated genes
This review introduces recently developed gene conversion models of duplicated genes and discusses the problems covered in this review, which include the fixation process of a duplicated copy, copy number polymorphism, the fates of duplicate genes and single nucleotide polymorphism in duplicates genes. Expand
Hidden role of mutations in the evolutionary process.
Mutations not only alter allele frequencies in a genetic pool but may also determine the fate of an evolutionary process. Here we study which allele fixes in a one-step, one-way model including theExpand
Ohno's dilemma: Evolution of new genes under continuous selection
A model is described by which selection continuously favors both maintenance of the duplicate copy and divergence of that copy from the parent gene, which would restrict the freedom to diverge. Expand
The Effect of Recurrent Mutations on Genetic Diversity in a Large Population of Varying Size
Recurrent mutations are a common phenomenon in population genetics. They may be at the origin of the fixation of a new genotype, if they give a phenotypic advantage to the carriers of the newExpand
Evolution of Genetic Redundancy : The Relevance of Complexity in Genotype-Phenotype Mapping
This study evaluates an evolutionary model with high-dimensional genotype?phenotype mapping (GPM) by applying a replica method to deal with quenched randomness, demonstrating that genetic redundancy can have higher population fitness under complex GPM, which tends to favor gene duplication in selection processes. Expand
The Role of Mutation Bias in Adaptive Evolution.
Little support is found for mutation bias as an independent force in adaptive evolution, although it can interact with selection under conditions of small population size and when standing genetic variation is limited, entirely consistent with standard evolutionary theory. Expand
Enhanced fixation and preservation of a newly arisen duplicate gene by masking deleterious loss-of-function mutations.
It is inferred that masking deleterious loss-of-function mutations give duplicate genes an immediate selective advantage and, together with effects of increased gene dosage, would predominantly determine the fates of the duplicate genes in the early phase of their evolution. Expand


The Possible Modification of the Response of the Wild Type to Recurrent Mutations
The observed behavior of multiple allelomorphs largely supports, though that of specific modifiers seems to oppose, the view that complete dominance generally may be regarded as a product of such selective modification. Expand
Fisher's Theory of Dominance
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Among the phenomena which can be accounted for by these phenomena are the disappearance of useless organs, recapitulation and the fact that the heterogametic sex is usually male
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