The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation.

@article{Greggio2008ThePD,
  title={The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation.},
  author={Elisa Greggio and Ibardo Zambrano and Alice Kaganovich and Alexandra G Beilina and Jean-Marc Taymans and Veronique Dani{\"e}ls and Patrick Lewis and Shushant Jain and Jinhui Ding and Ali F Syed and Kelly Jean Thomas and Veerle Baekelandt and Mark R Cookson},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 24},
  pages={16906-14}
}
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and apparently sporadic Parkinson disease. LRRK2 is a multidomain protein kinase with autophosphorylation activity. It has previously been shown that the kinase activity of LRRK2 is required for neuronal toxicity, suggesting that understanding the mechanism of kinase activation and regulation may be important for the development of specific kinase inhibitors for Parkinson disease treatment. Here, we show that LRRK2… CONTINUE READING

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