The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.

  title={The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.},
  author={Hossein Aleyasin and Maxime W. C. Rousseaux and Maryam Phillips and Raymond H. Kim and Ross J Bland and Steve M Callaghan and Ruth S Slack and Matthew John During and Tak W Mak and David S. Park},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 47},
Recent evidence has indicated that common mechanisms play roles among multiple neurological diseases. However, the specifics of these pathways are not completely understood. Stroke is caused by the interruption of blood flow to the brain, and cumulative evidence supports the critical role of oxidative stress in the ensuing neuronal death process. DJ-1 (PARK7) has been identified as the gene linked to early-onset familial Parkinson's disease. Currently, our work also shows that DJ-1 is central… CONTINUE READING


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