The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression

@inproceedings{Gao2017ThePV,
  title={The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression},
  author={Yu-Lei Gao and Bin Lu and Jian-Hua Zhai and Yan-Cun Liu and Hai-Xia Qi and Ying Yao and Yan-Fen Chai and Song-Tao Shou},
  booktitle={Mediators of inflammation},
  year={2017}
}
Cellular immunosuppression appears to be involved in sepsis and sepsis-induced multiple organ dysfunction syndrome (MODS). Recent evidence showed that parenteral vitamin C (Vit C) had the ability to attenuate sepsis and sepsis-induced MODS. Herein, we investigated the impact of parenteral Vit C on cellular immunosuppression and the therapeutic value in sepsis. Using cecal ligation and puncture (CLP), sepsis was induced in WT and Gulo-/- mice followed with 200 mg/Kg parenteral Vit C… CONTINUE READING
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