The Paramecium Germline Genome Provides a Niche for Intragenic Parasitic DNA: Evolutionary Dynamics of Internal Eliminated Sequences

@inproceedings{Arnaiz2012ThePG,
  title={The Paramecium Germline Genome Provides a Niche for Intragenic Parasitic DNA: Evolutionary Dynamics of Internal Eliminated Sequences},
  author={Olivier Arnaiz and Nathalie Mathy and C{\'e}line Baudry and Sophie Malinsky and Jean-Marc Aury and Cyril Denby Wilkes and Olivier A Garnier and Karine Labadie and Benjamin E. Lauderdale and Anne Le Mou{\"e}l and Antoine Marmignon and Mariusz Nowacki and Julie Poulain and Malgorzata Prajer and Patrick Wincker and E. Meyer and Sandra Duharcourt and Laurent Duret and Mireille B{\'e}termier and Linda Sperling},
  booktitle={PLoS genetics},
  year={2012}
}
Insertions of parasitic DNA within coding sequences are usually deleterious and are generally counter-selected during evolution. Thanks to nuclear dimorphism, ciliates provide unique models to study the fate of such insertions. Their germline genome undergoes extensive rearrangements during development of a new somatic macronucleus from the germline micronucleus following sexual events. In Paramecium, these rearrangements include precise excision of unique-copy Internal Eliminated Sequences… CONTINUE READING

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