The Par Complex and Integrins Direct Asymmetric Cell Division in Adult Intestinal Stem Cells

@inproceedings{Goulas2012ThePC,
  title={The Par Complex and Integrins Direct Asymmetric Cell Division in Adult Intestinal Stem Cells},
  author={Spyros Goulas and Ryan Conder and Juergen A. Knoblich},
  booktitle={Cell stem cell},
  year={2012}
}
The adult Drosophila midgut is maintained by intestinal stem cells (ISCs) that generate both self-renewing and differentiating daughter cells. How this asymmetry is generated is currently unclear. Here, we demonstrate that asymmetric ISC division is established by a unique combination of extracellular and intracellular polarity mechanisms. We show that Integrin-dependent adhesion to the basement membrane induces cell-intrinsic polarity and results in the asymmetric segregation of the Par… CONTINUE READING
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