The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins

  title={The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins},
  author={Oliver Rocks and Marc Gerauer and Nachiket Vartak and Sebastian Koch and Z Huang and Markos Pechlivanis and J. L. Kuhlmann and Lucas Brunsveld and Anchal Chandra and Bernhard Ellinger and Herbert Waldmann and Philippe I. H. Bastiaens},
Reversible S-palmitoylation of cysteine residues critically controls transient membrane tethering of peripheral membrane proteins. Little is known about how the palmitoylation machinery governs their defined localization and function. We monitored the spatially resolved reaction dynamics and substrate specificity of the core mammalian palmitoylation machinery using semisynthetic substrates. Palmitoylation is detectable only on the Golgi, whereas depalmitoylation occurs everywhere in the cell… CONTINUE READING
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Added in Proof The data referred to throughout as ‘‘P.I.H.B. and H.W., unpublished data’

F. Dekker, O. Rocks, +7 authors B Schölermann

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