The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins

@article{Rocks2010ThePM,
  title={The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins},
  author={Oliver Rocks and Marc Gerauer and Nachiket Vartak and Sebastian Koch and Z Huang and Markos Pechlivanis and J. L. Kuhlmann and Lucas Brunsveld and Anchal Chandra and Bernhard Ellinger and Herbert Waldmann and Philippe I. H. Bastiaens},
  journal={Cell},
  year={2010},
  volume={141},
  pages={458-471}
}
Reversible S-palmitoylation of cysteine residues critically controls transient membrane tethering of peripheral membrane proteins. Little is known about how the palmitoylation machinery governs their defined localization and function. We monitored the spatially resolved reaction dynamics and substrate specificity of the core mammalian palmitoylation machinery using semisynthetic substrates. Palmitoylation is detectable only on the Golgi, whereas depalmitoylation occurs everywhere in the cell… CONTINUE READING
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References

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Showing 1-10 of 55 references

Discovery of protein-palmitoylating enzymes

Pflügers Archiv - European Journal of Physiology • 2008
View 6 Excerpts
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Palmitoylation: policing protein stability and traffic

Nature Reviews Molecular Cell Biology • 2007
View 5 Excerpts
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Added in Proof The data referred to throughout as ‘‘P.I.H.B. and H.W., unpublished data’

F. Dekker, O. Rocks, +7 authors B Schölermann
2010

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