The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast

@inproceedings{Sadeghi2015ThePC,
  title={The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast},
  author={Laia Sadeghi and Punit Prasad and Karl Ekwall and Amikam Cohen and J. Peter Svensson},
  booktitle={EMBO reports},
  year={2015}
}
The maintenance of open and repressed chromatin states is crucial for the regulation of gene expression. To study the genes involved in maintaining chromatin states, we generated a random mutant library in Schizosaccharomyces pombe and monitored the silencing of reporter genes inserted into the euchromatic region adjacent to the heterochromatic mating type locus. We show that Leo1-Paf1 [a subcomplex of the RNA polymerase II-associated factor 1 complex (Paf1C)] is required to prevent the… CONTINUE READING
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