The PYRIN domain: a novel motif found in apoptosis and inflammation proteins

@article{Bertin2000ThePD,
  title={The PYRIN domain: a novel motif found in apoptosis and inflammation proteins},
  author={John J. Bertin and Peter Southborough Distefano},
  journal={Cell Death and Differentiation},
  year={2000},
  volume={7},
  pages={1273-1274}
}
Modular protein-protein interaction domains play an important role in many intracellular signal transduction pathways. In apoptosis signaling pathways, three major families of protein modules have been identified thus far: the death domain, the death effector domain (DED) and the caspase recruitment domain (CARD). These protein modules of approximately 100 amino acids in length function to mediate homotypic, protein-protein interactions between signaling components leading to the activation of… CONTINUE READING
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