The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.

@article{Almeida2015ThePD,
  title={The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.},
  author={L{\'u}cia Maria Vieira de Almeida and Sonal Khare and Alexander V Misharin and Rajul Patel and Rojo A. Ratsimandresy and Melissa C. Wallin and Harris Perlman and David Greaves and Hal M. Hoffman and Andrea Dorfleutner and Christian Stehlik},
  journal={Immunity},
  year={2015},
  volume={43 2},
  pages={264-76}
}
In response to infections and tissue damage, ASC-containing inflammasome protein complexes are assembled that promote caspase-1 activation, IL-1β and IL-18 processing and release, pyroptosis, and the release of ASC particles. However, excessive or persistent activation of the inflammasome causes inflammatory diseases. Therefore, a well-balanced inflammasome response is crucial for the maintenance of homeostasis. We show that the PYD-only protein POP1 inhibited ASC-dependent inflammasome… CONTINUE READING
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