The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples.

@article{RodrguezRodrguez2011ThePR,
  title={The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples.},
  author={Luis Rodr{\'i}guez-Rodr{\'i}guez and Wan Rohani Wan Taib and Ruth Topless and Sophia Steer and Mar{\'i}a Francisca Gonz{\'a}lez-Escribano and Alejandro Balsa and Dora Pascual-Salcedo and Miguel A Gonz{\'a}lez-Gay and Enrique Raya and Benjam{\'i}n Fern{\'a}ndez-Guti{\'e}rrez and Isidoro Gonz{\'a}lez-{\'A}lvaro and Nunzio Bottini and Torsten Witte and Marte K Viken and Marieke J. H. Coenen and Piet van Riel and Barbara Franke and Martin den Heijer and Timothy R. D. Radstake and Paul Wordsworth and Benedicte A Lie and Tony Raymond Merriman and Javier Mart{\'i}n},
  journal={Arthritis and rheumatism},
  year={2011},
  volume={63 2},
  pages={
          365-72
        }
}
  • Luis Rodríguez-Rodríguez, Wan Rohani Wan Taib, +20 authors Javier Martín
  • Published in Arthritis and rheumatism 2011
  • Medicine
  • OBJECTIVE Recently, a functional PTPN22 variant (R263Q; rs33996649) was found to be associated with systemic lupus erythematosus (SLE). This study was undertaken to analyze the influence of this polymorphism on the risk of rheumatoid arthritis (RA). METHODS RA patients (n = 5,579) were recruited from outpatient clinics from 6 different countries (Spain, New Zealand, the UK, Norway, The Netherlands, and Germany). Healthy controls (n = 5,392) were recruited from the same areas. There was 100… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 44 CITATIONS

    The PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis

    VIEW 7 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    PTPN22 1858 C/T Exon Polymorphism is not Associated with Graves' Disease in Kashmiri population

    VIEW 5 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Identification and structure–function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22

    VIEW 1 EXCERPT
    CITES BACKGROUND