The PTEN tumor suppressor inhibits human airway smooth muscle cell migration.

@article{Lan2010ThePT,
  title={The PTEN tumor suppressor inhibits human airway smooth muscle cell migration.},
  author={Haibing Lan and Haohai Zhong and Yang Gao and Dunqiang Ren and Lili Chen and Dacheng Zhang and Wenyan Lai and J Xu and Yaling Luo},
  journal={International journal of molecular medicine},
  year={2010},
  volume={26 6},
  pages={893-9}
}
Airway remodeling in asthma is characterized by increased airway smooth muscle (ASM) mass, accompanied by cell migration. It is well known that the proliferation and migration of ASM cells (ASMCs) play a key role in airway remodeling, but the precise mechanism modulating these cellular events remains unclear. One of the genes most likely to be involved in this process is the phosphatase and tensin homolog (PTEN) gene, whose deletion from chromosome 10 can inhibit the proliferation and migration… CONTINUE READING