The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy.

Abstract

Aberrant activation of the PI3K/Akt/mTOR pathway is observed in several cancers and hyper proliferative disorders. PTEN, a tumor suppressor gene, negatively regulates the PI3K/Akt/mTOR pathway. Inhibitors of various components of this pathway are currently being used for cancer therapy. However, the use of these small molecule inhibitors remains limited due… (More)
DOI: 10.1039/c3mb70267g

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