The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene.

@article{Li1998ThePT,
  title={The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene.},
  author={Jianfeng Li and Laura R. Simpson and Minoru Takahashi and Christa Miliaresis and Michael P. Myers and Nicholas K. Tonks and Ramon Parsons},
  journal={Cancer research},
  year={1998},
  volume={58 24},
  pages={5667-72}
}
PTEN/MMAC1 is a tumor suppressor gene that is mutated in a variety of cancers. PTEN encodes a phosphatase that recognizes phosphoprotein substrates and the phospholipid, phosphatidylinositol-3,4,5-triphosphate. PTEN inhibited cell growth and/or colony formation in all of the epithelial lines tested with one exception. The decrease in cellular proliferation… CONTINUE READING