The PS2 integrin ligand tiggrin is required for proper muscle function in Drosophila.

  title={The PS2 integrin ligand tiggrin is required for proper muscle function in Drosophila.},
  author={Thomas A. Bunch and Michael W Graner and Liselotte I. Fessler and John H. Fessler and Kim D Schneider and Arthur Kerschen and Lisa Choy and Brendan Burgess and Danny L. Brower},
  volume={125 9},
Tiggrin is a novel extracellular matrix ligand for the Drosophila PS2 integrins. We have used flanking P elements to generate a precise deletion of tiggrin. Most flies lacking tiggrin die as larvae or pupae. A few adults do emerge and these appear to be relatively normal, displaying only misshapen abdomens and a low frequency of wing defects. Examination of larvae shows that muscle connections, function and morphology are defective in tiggrin mutants. Muscle contraction waves that extend the… CONTINUE READING


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