The PROGINS progesterone receptor gene polymorphism and idiopathic recurrent miscarriage.

@article{Kurz2001ThePP,
  title={The PROGINS progesterone receptor gene polymorphism and idiopathic recurrent miscarriage.},
  author={Christine Kurz and Clemens B Tempfer and S Boecskoer and Gertrud Unfried and Fritz Nagele and Lukas Hefler},
  journal={Journal of the Society for Gynecologic Investigation},
  year={2001},
  volume={8 5},
  pages={295-8}
}
OBJECTIVE Progesterone inhibits lymphocyte cytotoxicity, natural killer cell degranulation, and release of proinflammatory cytokines and has been shown to protect against spontaneous miscarriage. We investigated the association between idiopathic recurrent miscarriage (IRM) and the PROGINS 306 base pair insertion polymorphism in intron G of the progesterone receptor gene, which is known to segregate with progesterone-dependent neoplasms. METHODS In a case-control study we investigated 125… CONTINUE READING