The PROGINS polymorphism of the human progesterone receptor diminishes the response to progesterone.

@article{Romano2007ThePP,
  title={The PROGINS polymorphism of the human progesterone receptor diminishes the response to progesterone.},
  author={Andrea Romano and Bert Delvoux and Douglas Henry Fischer and Patrick G Groothuis},
  journal={Journal of molecular endocrinology},
  year={2007},
  volume={38 1-2},
  pages={
          331-50
        }
}
The human progesterone receptor (PR) is a ligand-dependent transcription factor and two isoforms, (PRA and PRB), can be distinguished. PROGINS, a PR polymorphic variant, affects PRA and PRB and acts as a risk-modulating factor in several gynaecological disorders. Little is known about the functional consequences of this variant. Here, we characterise the properties of PROGINS with respect to transcription, mRNA maturation, protein activity and proliferation. PROGINS is characterised by a 320 bp… CONTINUE READING

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