The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma.

@article{Justilien2014ThePA,
  title={The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma.},
  author={Verline Justilien and Michael P Walsh and Syed Amaan Ali and Elizabeth A Thompson and Nicole Robin Murray and Alan P. Fields},
  journal={Cancer cell},
  year={2014},
  volume={25 2},
  pages={
          139-51
        }
}
We report that two oncogenes coamplified on chromosome 3q26, PRKCI and SOX2, cooperate to drive a stem-like phenotype in lung squamous cell carcinoma (LSCC). Protein kinase Cι (PKCι) phosphorylates SOX2, a master transcriptional regulator of stemness, and recruits it to the promoter of Hedgehog (Hh) acyltransferase (HHAT) that catalyzes the rate-limiting step in Hh ligand production. PKCι-mediated SOX2 phosphorylation is required for HHAT promoter occupancy, HHAT expression, and maintenance of… CONTINUE READING
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