The PPARγ agonist protects cardiomyocytes from oxidative stress and apoptosis via thioredoxin overexpression.

Abstract

Oxidative stress has been implicated in the pathogenesis of various cardiovascular diseases, including ischemic heart disease and heart failure. The peroxisome proliferator-activated receptor gamma (PPARγ) agonist improves insulin sensitivity and limits tissue inflammation and cellular apoptosis, but there are few data on the relationship between the PPAR… (More)

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