The PP2A inhibitor SET regulates natural killer cell IFN-γ production

@article{Trotta2007ThePI,
  title={The PP2A inhibitor SET regulates natural killer cell IFN-γ production},
  author={Rossana Trotta and David Ciarlariello and Jessica Dal Col and Jeffrey W. Allard and Paolo Neviani and Ramasamy Santhanam and H. C. Mao and Brian Becknell and Jianhua Yu and Amy K. Ferketich and Brittany Thomas and Aalok S Modi and Bradley W. Blaser and Danilo Perrotti and Michael A Caligiuri},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={2397 - 2405}
}
  • Rossana Trotta, David Ciarlariello, +12 authors Michael A Caligiuri
  • Published in
    The Journal of experimental…
    2007
  • Biology, Medicine
  • The Journal of Experimental Medicine
  • Monokines (i.e., interleukin [IL]-12, -18, and -15) induce natural killer (NK) cells to produce interferon-gamma (IFN-gamma), which is a critical factor for immune surveillance of cancer and monocyte clearance of infection. We show that SET, which is a potent inhibitor of protein phosphatase type 2A (PP2A) activity, is highly expressed in human CD56bright NK cells, which produce more IFN-gamma than CD56dim NK cells. SET was up-regulated upon monokine stimulation of primary human NK cells… CONTINUE READING

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