The PP2A Inhibitor I2PP2A Is Essential for Sister Chromatid Segregation in Oocyte Meiosis II

@article{Chambon2013ThePI,
  title={The PP2A Inhibitor I2PP2A Is Essential for Sister Chromatid Segregation in Oocyte Meiosis II},
  author={Jean-Philippe Chambon and Sandra A. Touati and St{\'e}phane C Berneau and Damien Cladi{\`e}re and C{\'e}line H{\'e}bras and Rachel Groeme and Alex McDougall and Katja Wassmann},
  journal={Current Biology},
  year={2013},
  volume={23},
  pages={485-490}
}
Haploid gametes are generated through two consecutive meiotic divisions, with the segregation of chromosome pairs in meiosis I and sister chromatids in meiosis II. Separase-mediated stepwise removal of cohesion, first from chromosome arms and later from the centromere region, is a prerequisite for maintaining sister chromatids together until their separation in meiosis II [1]. In all model organisms, centromeric cohesin is protected from separase-dependent removal in meiosis I through the… CONTINUE READING