The POU protein Oct-6 is a nucleocytoplasmic shuttling protein

  title={The POU protein Oct-6 is a nucleocytoplasmic shuttling protein},
  author={Constanze Baranek and Elisabeth Sock and Michael Wegner},
  journal={Nucleic Acids Research},
  pages={6277 - 6286}
Like many POU domain proteins, Oct-6 plays important roles during vertebrate development. In accord with its function as a transcriptional regulator during neurogenesis and myelination, Oct-6 is predominantly found in the nucleus. Nuclear import is mediated by a nuclear localization signal at the N-terminal end of the POU homeodomain. Here we show, that Oct-6 in addition contains a nuclear export signal so that Oct-6 is able to shuttle constantly between nucleus and cytoplasm. This nuclear… CONTINUE READING


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