The POPX2 phosphatase regulates cancer cell motility and invasiveness.

  title={The POPX2 phosphatase regulates cancer cell motility and invasiveness.},
  author={Agatha Susila and Hei Chan and Andrew Xiong-Wen Loh and Hui-Qun Phang and Ee Tsin Wong and Vinay Tergaonkar and Cheng-Gee Koh},
  journal={Cell cycle},
  volume={9 1},
Rho GTP ases play major roles in the regulation of actin cytoskeleton, cell movement and cell cycle. PAK, one of the effector kinases of these small GTP ases, has long been associated with different types of cancer. Therefore, it is likely that deregulation of PAK activity or expression may contribute to the development of cancer. POP X2, a PP 2C serine/threonine phosphatase, is known to dephosphorylate PAK and downregulate its activity. We find that POPX2 is expressed in a wide variety of… CONTINUE READING


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