The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication

@inproceedings{Clerzius2012ThePA,
  title={The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication},
  author={Guerline Clerzius and Eileen Shaw and A{\"i}cha Daher and Samantha Burugu and Jean-François G{\'e}linas and Thornin Ear and Lucile Sinck and Jean-Pierre Routy and Andrew J Mouland and Rekha C Patel and Anne Gatignol},
  booktitle={Retrovirology},
  year={2012}
}
BackgroundHIV-1 translation is modulated by the activation of the interferon (IFN)-inducible Protein Kinase RNA-activated (PKR). PKR phosphorylates its downstream targets, including the alpha subunit of the eukaryotic translation Initiation Factor 2 (eIF2α), which decreases viral replication. The PKR Activator (PACT) is known to activate PKR after a cellular stress. In lymphocytic cell lines, HIV-1 activates PKR only transiently and not when cells replicate the virus at high levels. The… CONTINUE READING
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RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2013
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