The PKC gene module: molecular biosystematics to resolve its T cell functions.

@article{Baier2003ThePG,
  title={The PKC gene module: molecular biosystematics to resolve its T cell functions.},
  author={Gottfried Baier},
  journal={Immunological reviews},
  year={2003},
  volume={192},
  pages={64-79}
}
The distinct protein kinase C (PKC) multigene family (PKC gene module) is known to be the 'classic' intracellular receptor for mitogenic phorbol esters, and it is widely accepted in the scientific community that the 'PKC effect' is essential in activation, differentiation, adhesion and motility, as well as in cellular survival, of T cells. Nevertheless, the first concepts about PKC isotype heterogeneity of cellular localization and function emerged only recently, when the PKC-theta pathways… CONTINUE READING

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