The PINCH-ILK-parvin complexes: assembly, functions and regulation.

  title={The PINCH-ILK-parvin complexes: assembly, functions and regulation.},
  author={Chuanyue Wu},
  journal={Biochimica et biophysica acta},
  volume={1692 2-3},
  • Chuanyue Wu
  • Published 2004 in Biochimica et biophysica acta
Cell-extracellular matrix (ECM) adhesion is mediated by transmembrane cell adhesion receptors (e.g., integrins) and receptor proximal cytoplasmic proteins. Over the past several years, studies using biochemical, structural, cell biological and genetic approaches have provided important evidence suggesting crucial roles of integrin-linked kinase (ILK), PINCH and CH-ILKBP/actopaxin/affixin/parvin (abbreviated as parvin herein) in ECM control of cell behavior. One general theme emerging from these… CONTINUE READING