The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array.

@article{Arcus2011ThePR,
  title={The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array.},
  author={Vickery L Arcus and Joanna L. McKenzie and Jennifer R. Robson and Gregory. M. Cook},
  journal={Protein engineering, design & selection : PEDS},
  year={2011},
  volume={24 1-2},
  pages={33-40}
}
The PIN-domains are small proteins of ~130 amino acids that are found in bacteria, archaea and eukaryotes and are defined by a group of three strictly conserved acidic amino acids. The conserved three-dimensional structures of the PIN-domains cluster these acidic residues in an enzymatic active site. PIN-domains cleave single-stranded RNA in a sequence-specific, Mg²+- or Mn²+-dependent manner. These ribonucleases are toxic to the cells which express them and to offset this toxicity, they are co… CONTINUE READING

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