The PIDDosome activates p53 in response to supernumerary centrosomes.


Centrosomes, the main microtubule-organizing centers in animal cells, are replicated exactly once during the cell division cycle to form the poles of the mitotic spindle. Supernumerary centrosomes can lead to aberrant cell division and have been causally linked to chromosomal instability and cancer. Here, we report that an increase in the number of mature… (More)
DOI: 10.1101/gad.289728.116


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@article{Fava2017ThePA, title={The PIDDosome activates p53 in response to supernumerary centrosomes.}, author={Luca L. Fava and F. William Schuler and Valentina Sladky and Manuel D. Haschka and Claudia Soratroi and Lisa Eiterer and Egon Demetz and Guenter Weiss and Stephan Geley and Erich A. Nigg and Andreas Villunger}, journal={Genes & development}, year={2017}, volume={31 1}, pages={34-45} }